Article

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)

2024-10-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of HF cases, with no effective treatments. The ZSF1-obese rat model recapitulates numerous clinical features of HFpEF including hypertension, obesity, metabolic syndrome, exercise intolerance, and LV diastolic dysfunction. Here, we utilized a systems-biology approach to define the early metabolic and tr...

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Literature Corpus work: ce2d87cf-52e5-52eb-8bb8-8de586f6e108
DOI: 10.1101/2024.10.25.619450

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