Article

Human primary plaque cell cultures to study mechanisms of atherosclerosis

2023-02-13

Abstract excerpt

Plaque smooth muscle cells are critical players in the initiation and advancement of atherosclerotic disease. They produce extracellular matrix (ECM) components, which play a role in lesion progression and stabilization. Despite clear phenotypic differences between plaque smooth muscle cells and vascular smooth muscle cells (VSMCs), VSMCs are still widely used as a model system in atherosclerotic research. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c3b1eec-966e-5878-be6d-1e9cdb22141c
DOI: 10.1101/2023.02.09.527800

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human primary plaque cell cultures to study mechanisms of atherosclerosisDOI 10.1101/2023.02.09.527800Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populationsSemantic proximity Read

Decoding the transcriptome of atherosclerotic plaque at single-cell resolutionSemantic proximity Read

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosisSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment.Semantic proximity Read

Atherosclerotic fibrous plaques in females are characterized by endothelial-to-mesenchymal transition and linked to smokingSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read

Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formationSemantic proximity Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic stateSemantic proximity Read