Article

KATMAP: Inferring splicing factor activity and regulatory targets from knockdown data

2024-06-29

Abstract excerpt

Typical RNAseq experiments uncover hundreds of splicing changes, reflecting underlying changes in splicing factor (SF) activity. Understanding transcriptomic variation in terms of SF activity requires elucidating the rules by which each SF impacts splicing. Here we present an interpretable regression model, KATMAP, which models splicing changes transcriptome-wide in terms of changes in SF binding and resulting alt...

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Literature Corpus work: 7bf3bffb-c826-5802-98ec-37ff822344d2
DOI: 10.1101/2024.06.25.600605

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