Article

Exon inclusion signatures enable accurate estimation of splicing factor activity

2024-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Splicing factors control exon inclusion in messenger RNAs, shaping transcriptome and proteome diversity. Their catalytic activity is regulated by multiple layers, making single-omic measurements on their own fall short in identifying which splicing factors underlie a phenotype. Here, we posit that splicing factor activity can be estimated from changes in exon inclusion. To test this hypothesis,...

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Identifiers and source

Literature Corpus work: 9d442db5-9156-592d-b580-2d9894c31798
DOI: 10.1101/2024.06.21.600051

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