Article

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

2023-09-26

Abstract excerpt

Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics. We describe a foundation model for RNA biology, “BigRNA”, which was trained on thousands of genome-matched datasets to predict tissue-specific RNA expression, splicing, microRNA sites, and RNA binding protein specifici...

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Literature Corpus work: 80356e17-8c2b-5ea9-bd9e-97bfb4bbd3bd
DOI: 10.1101/2023.09.20.558508

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