Article

Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing

2023-08-20

Abstract excerpt

<h4>Summary</h4> Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions, but their exact binding locations and activities are difficult to predict. Here, we describe a modular splicing architecture that leverages in vitro -derived RNA affinity models for 79 human RBPs and the annotated human genome to produce improved models of RBP binding and activity. Binding and activity are mo...

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Literature Corpus work: 50207c07-788b-559d-8cd8-6a97add5a28b
DOI: 10.1101/2023.08.20.553608

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