Article

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

2023-09-25

Abstract excerpt

<title>Abstract</title> <p>Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics. We describe a foundation model for RNA biology, “BigRNA”, which was trained on thousands of genome-matched datasets to predict tissue-specific RNA expression, splicing, microRNA sites, and R...

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Literature Corpus work: f489da8d-8d41-5642-ba66-d0977af25fdd
DOI: 10.21203/rs.3.rs-3373630/v1

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