Article

Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1–PPARγ pathway

2026-07-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introductions</h4> Aortic dissection (AD) is a life-threatening vascular disease with limited therapeutic targets. Apolipoprotein H (APOH), a circulating glycoprotein implicated in lipid metabolism, has not been studied in AD. <h4>Methods</h4> Plasma APOH levels and aortic deposition were examined in AD patients. A β-aminopropionitrile (BAPN) and angiotensin II (Ang-II)-induced mouse AD mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bd6fa98-610f-513d-83e1-87fc9230bbd2
DOI: 10.64898/2026.07.16.739043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1–PPARγ pathwayDOI 10.64898/2026.07.16.739043Read

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissectionSemantic proximity Read

Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch.Semantic proximity Read

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.Semantic proximity Read

Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.Semantic proximity Read

AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin SignalingSemantic proximity Read

The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and ruptureSemantic proximity Read

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissectionSemantic proximity Read

ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch.Semantic proximity Read

Integrative mediation and multi-omics analysis to decode Aortic dissection’s genetic causal phenotype and potential therapeutic targetsSemantic proximity Read

H3.3B controls aortic dissection progression by regulating vascular smooth muscle cells phenotypic transition and vascular inflammation.Semantic proximity Read

Emerging Role of Non-Coding RNAs in Aortic DissectionSemantic proximity Read

Loss of CASQ2 promotes vascular smooth muscle cell phenotypic switching in aortic dissection uncovered by integrated single-cell transcriptomics.Semantic proximity Read