Article
H3.3B controls aortic dissection progression by regulating vascular smooth muscle cells phenotypic transition and vascular inflammation.
Genomics - 1 Sept 2023
Zhang Xuelin, Che Yang, Mao Lin, Li Dandan, Deng Jianqing, Guo Yilong, Zhao Quanyi, Zhang Xingzhong, Wang Li, Gao Xiang, Chen Yinan, Zhang Tao
Abstract excerpt
Aortic dissection is a devastating cardiovascular disease with a high lethality. Histone variants maintain the genomic integrity and play important roles in development and diseases. However, the role of histone variants in aortic dissection has not been well identified. In the present study, H3f3b knockdown reduced the synthetic genes expression of VSMCs, while overexpressing H3f3b exacerbated the cellular...
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