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Article

Loss of CASQ2 promotes vascular smooth muscle cell phenotypic switching in aortic dissection uncovered by integrated single-cell transcriptomics.

BMC medical genomics - 13 Jun 2026

Chen Kaiyan, Wang Meixiang, Zhang Zhiyuan, Chen Yingquan, Zhu Hui, Yang Ting, Xia Yuan, Guo Maomao, Li Junchao

Abstract excerpt

BACKGROUND: Aortic dissection (AD) is a life-threatening cardiovascular disease with limited effective therapeutic options. Phenotypic switching of aortic vascular smooth muscle cells (VSMCs) from a contractile to a pathological state is a critical driver of AD progression. However, the molecular regulators governing this transition remain incompletely understood. This study aimed to identify a critical regulator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42288847
DOI: 10.1186/s12920-026-02410-w
PMCID: PMC13491616

Genes

CASQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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