Article
ACE2 deficiency inhibits thoracic aortic dissection by enhancing SIRT3 mediated inhibition of inflammation and VSCMs phenotypic switch.
Molecular medicine (Cambridge, Mass.) - 19 Sept 2024
Jiang Liqing, Lu Linhe, Xue Chao, Sun He, Ren Kai, Zhang Liyun, Zhu Hanzhao, Zhang Bin, Wang Xiaoya, Qiao Xinan, Peng Xiangyan, Liu Jincheng, Duan Weixun
Abstract excerpt
BACKGROUND: Thoracic aortic dissection (TAD) is an irreversible cardiovascular disorder with high mortality and morbidity. However, the molecular mechanisms remain elusive. Thus, identifying an effective therapeutic target to prevent TAD is especially critical. The purpose of this study is to elucidate the potential mechanism of inflammation and vascular smooth muscle cell (VSMCs) phenotypic switch in...
Topics
- Animals
- Angiotensin-Converting Enzyme 2
- Mice
- Aortic Dissection
- Myocytes, Smooth Muscle
- Disease Models, Animal
- Sirtuin 3
- Muscle, Smooth, Vascular
- Inflammation
- Aortic Aneurysm, Thoracic