Article

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

2025-04-23

Abstract excerpt

Aortic dissection (AD) is a cardiovascular disease with rapid onset and extremely high short-term mortality, currently lacking specific peripheral blood-based biomarkers and effective treatments. Here, our analysis of AD samples from animal models and human patients revealed elevated blood levels of CTHRC1, a protein secreted by vascular fibroblasts. Furthermore, CTHRC1 regulates the phenotypic switch of vascular...

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Literature Corpus work: d6d6b801-c9ce-59cb-b1df-6991a6248b82
DOI: 10.1101/2025.04.19.649636

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