Article

AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling

2025-04-01

Abstract excerpt

Aortic dissection (AD), a life-threatening cardiovascular emergency, continues to impose high mortality due to insufficient therapeutic options, as monotherapy targeting angiotensin II type 1 receptor (AT1R) demonstrates limited clinical efficacy. Utilizing single-cell RNA sequencing, we identified integrin β3 as a critical driver of AD progression, with expression levels positively correlated with disease severit...

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Literature Corpus work: 480a78cb-fde5-59c0-8e62-cbd07c0ad2c1
DOI: 10.1101/2025.03.26.645618

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