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Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Apr 2024

Dang Zhiqiao, Li Haijie, Xue Shishan, Shao Baowei, Ning Yansong, Su Guohai, Zhang Fengquan, Yu Wenqian, Leng Shuai

Abstract excerpt

Aortic aneurysm/dissection (AAD) is a serious cardiovascular condition characterized by rapid onset and high mortality rates. Currently, no effective drug treatment options are known for AAD. AAD pathogenesis is associated with the phenotypic transformation and abnormal proliferation of vascular smooth muscle cells (VSMCs). However, endogenous factors that contribute to AAD progression remain unclear. We aimed to...

Topics

Humans
Mice
Animals
Muscle, Smooth, Vascular
Aortic Dissection
Histone Deacetylases
Aortic Aneurysm
Phenotype
Myocytes, Smooth Muscle
Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Benzamides

Oxadiazoles

Source

Identifiers

PMID: 38460370
DOI: 10.1016/j.biopha.2024.116396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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