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Article

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype.

European heart journal - 7 Jul 2020

Yang Kehui, Ren Jun, Li Xin, Wang Zheng, Xue Li, Cui Sumei, Sang Wentao, Xu Tonghui, Zhang Jian, Yu Jieqiong, Liu Zhiping, Shang Haixia, Pang Jiaojiao, Huang Xiaoran, Chen Yuguo, Xu Feng

Abstract excerpt

AIMS: Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied with various risk factors for AAD including hypertension, atherosclerosis, and hypercholesterolaemia although direct correlation between the two remains elusive. METHODS AND RESULTS: Two independent case-control studies were conducted involving...

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Share to Aldehyde Dehydrogenase, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Identifiers

PMID: 32428930
DOI: 10.1093/eurheartj/ehaa352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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