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Article

Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2026

Zhang Yi, Wu Chunyan, Du Dongdong, Hu Jiayi, Li Zhiqing, Wang Yizeng, Li Bochuan, Mu Jiuke, Chen Xiongwen, Yu Ying, Wu Naishi, Zuo Shengkai

Abstract excerpt

BACKGROUND: Aortic dissection (AD) is a life-threatening condition and involves pathological vascular smooth muscle cell (VSMC) phenotypic switching from a contractile to a synthetic state. Although exercise confers broad cardiovascular benefits, its role in AD pathogenesis remains unclear. This study aimed to determine whether exercise attenuates AD by modulating VSMC phenotype and to elucidate the underlying...

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Source

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Identifiers

PMID: 41853865
DOI: 10.1161/ATVBAHA.125.324293
PMCID: PMC13098669

Genes

PDE5A
RUNX1
CNN1
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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