Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection

15 Dec 2021

Abstract excerpt

Rationale: While cell-cell interaction plays a critical role in physiology and disease, a comprehensive understanding of its dynamics in vascular homeostasis and diseases is yet absent. Methods: Here, by use of single-cell RNA-sequencing and multi-color staining, we delineate the cellular composition and spatial characterization of human aorta with or without aortic dissection (AD). Results: Scrutinization of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic aneurysm repair treatments
Share to Aortic Disease and Treatment Approaches
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34976220
DOI: 10.7150/thno.66059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissectionPMID 34976220Read ↗

Single‐Cell RNA ‐Seq Reveals Injuries in Aortic Dissection and Identifies PDGF Signalling Pathway as a Potential Therapeutic TargetSemantic proximity Read ↗

Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation.Semantic proximity Read ↗

Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan SyndromeSemantic proximity Read ↗

Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune InfiltrationSemantic proximity Read ↗

A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aortaSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic DissectionSemantic proximity Read ↗

Pathological Angiogenesis Precedes the Onset of Aortic DissectionSemantic proximity Read ↗

The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and ruptureSemantic proximity Read ↗

Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet's syndrome.Semantic proximity Read ↗

Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1–PPARγ pathwaySemantic proximity Read ↗

Integrative Omics Identifies Candidate Plasma Biomarkers and Cellular Targets Associated with Thoracic Aortic AneurysmSemantic proximity Read ↗

Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic AneurysmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.