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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

7 Feb 2020

Abstract excerpt

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease. Here, we focus on the role of MAPK pathways in modulating drug sensitivity and resistance in cancer. We briefly discuss new findings in the extracellular signaling-regulated kinase (ERK) pathway, but mainly focus on the mechanisms how stress...

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PMID: 32046099
DOI: 10.3390/ijms21031102

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