Article
Deciphering the genetic landscape of cancer--from genes to pathways.
Trends in genetics : TIG - 1 Oct 2009
Copeland Neal G, Jenkins Nancy A
Abstract excerpt
Advances in genomic technologies have made it possible to screen the entire cancer genome for mutations, leading to a better understanding of the genetic landscape of cancer. Emerging results suggest that the cancer genome is composed of a few commonly mutated genes and many infrequently mutated genes. Although the number of mutated genes in any one tumor is limited, there is much heterogeneity in the genes...
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