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Article

Precision drugging of the MAPK pathway in head and neck cancer

16 Mar 2022

Abstract excerpt

Abstract The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation, differentiation, and senescence. In human, germline defects of the pathway contribute to developmental and congenital head and neck disorders. Nearly 1/5 of head and neck squamous cell carcinoma (HNSCC) harbors MAPK pathway mutations, which are largely activating mutations. Yet, previous approaches targeting the MAPK...

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PMID: 35296678
DOI: 10.1038/s41525-022-00293-1

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