Article

Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibition

2025-04-09

Abstract excerpt

<h4>ABSTRACT</h4> EGFR is a proto-oncogene that is mutationally activated in a variety of cancers. Small molecule inhibitors targeting EGFR can be effective in slowing the progression of disease, and in some settings these drugs even cause dramatic tumor regression. However, responses to EGFR inhibitors are rarely durable, and the mechanisms contributing to response variation remain unclear. In particular, severa...

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Literature Corpus work: 6560a2e0-f77f-57fd-b692-fbcb5cfa156c
DOI: 10.1101/2025.04.04.647273

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