Article

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

2020-01-28

Abstract excerpt

Microglia express muscarinic G protein-coupled receptors (GPCRs) that sense cholinergic activity and are activated by acetylcholine to potentially regulate microglial functions. Knowledge about how distinct types of muscarinic GPCR signaling regulate microglia function in vitro and in vivo is still poor, partly due to the fact that some of these receptors are also present in astrocytes and neurons. We generated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b97d1c8-ca4b-524d-89d2-177471f91878
DOI: 10.1101/2020.01.27.921809

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male miceDOI 10.1101/2020.01.27.921809Read

Astrocyte-derived TNF and glutamate critically modulate microglia reactivity by methamphetamineSemantic proximity Read

CSF1R inhibitor levels determine sex-specific phenotype of resilient microglia and neurofunctional rescue leading to extended survival in tauopathy miceSemantic proximity Read

Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice.Semantic proximity Read

A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitorsSemantic proximity Read

Repeated Activation of Pyramidal Neurons in the Prefrontal Cortex Alters Microglial Phenotype in Male Mice.Semantic proximity Read

Targeting Microglial Activation in Drug-Resistant Epilepsy: Emerging Therapeutic StrategiesSemantic proximity Read

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizuresSemantic proximity Read

The Role of Microglia in Neurodevelopmental Disorders and their TherapeuticsSemantic proximity Read

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammationSemantic proximity Read

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia.Semantic proximity Read

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model.Semantic proximity Read

Chronic activation of astrocytic G <sub>q</sub> GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseasesSemantic proximity Read