Article

CSF1R inhibitor levels determine sex-specific phenotype of resilient microglia and neurofunctional rescue leading to extended survival in tauopathy mice

2021-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Microglia are central to pathogenesis in many neurological conditions. Drugs targeting colony- stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease models have shown mixed outcomes, thus the therapeutic potential of this approach remains unclear. Here, CSF1R inhibitors were evaluated in tauopathy mice using multiple dosing schemes, drug analogs, and long...

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Literature Corpus work: 462e9c6b-7eda-5fad-b06d-b4f65e5fbfb3
DOI: 10.1101/2021.03.20.436288

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