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Article

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model.

International immunopharmacology - 1 Oct 2017

Aryanpour Roya, Pasbakhsh Parichehr, Zibara Kazem, Namjoo Zeinab, Beigi Boroujeni Fatemeh, Shahbeigi Saeed, Kashani Iraj Ragerdi, Beyer Cordian, Zendehdel Adib

Abstract excerpt

Demyelination of the central nervous system (CNS) has been associated to reactive microglia in neurodegenerative disorders, such as multiple sclerosis (MS). The M1 microglia phenotype plays a pro-inflammatory role while M2 is involved in anti-inflammatory processes in the brain. In this study, CPZ-induced demyelination mouse model was used to investigate the effect of progesterone (PRO) therapy on microglia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28830026
DOI: 10.1016/j.intimp.2017.08.007

Genes

CPZ
NLRP3
MBP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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