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Article

Repeated Activation of Pyramidal Neurons in the Prefrontal Cortex Alters Microglial Phenotype in Male Mice.

The Journal of pharmacology and experimental therapeutics - 17 Jan 2024

Bollinger Justin L, Horchar Matthew J, Wohleb Eric S

Abstract excerpt

Aberrant neuronal activity in the cortex alters microglia phenotype and function in several contexts, including chronic psychologic stress and neurodegenerative disease. Recent findings even suggest that heightened levels of neuronal activity spur microglia to phagocytose synapses, with potential impacts on cognition and behavior. Thus, the present studies were designed to determine if activation of neurons...

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Identifiers

PMID: 38129124
DOI: 10.1124/jpet.123.001759
PMCID: PMC10801771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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