Article

CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures

2025-05-21

Abstract excerpt

Seizure-associated cognitive co-morbidities can substantially reduce the quality of life in people with epilepsy. Neuroinflammation is an invariant feature of all chronic neurologic diseases, including epilepsy, and acute brain insults, including status epilepticus (SE). The generalized seizures of SE trigger a robust inflammatory response involving astrocytosis, erosion of the blood-brain barrier (BBB), activatio...

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Literature Corpus work: 82c6d9d9-28a3-59c7-b41d-b781b0d00007
DOI: 10.1101/2025.05.19.655010

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