Article
Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation
2017-08-16
Abstract excerpt
It is widely assumed that the addition of DNA methylation at CpG rich gene promoters silences gene transcription. However, this conclusion is largely drawn from the observation that promoter DNA methylation inversely correlates with gene expression in natural conditions. The effect of induced DNA methylation on endogenous promoters has yet to be comprehensively assessed. Here, we induced the simultaneous methylati...
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Identifiers and source
- Literature Corpus work
- 7b760686-cf98-5f67-b51e-bf6f356f4a7c
- DOI
- 10.1101/170506