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Article

Targets and dynamics of promoter DNA methylation during early mouse development.

Nature genetics - 1 Dec 2010

Borgel Julie, Guibert Sylvain, Li Yufeng, Chiba Hatsune, Schübeler Dirk, Sasaki Hiroyuki, Forné Thierry, Weber Michael

Abstract excerpt

DNA methylation is extensively reprogrammed during the early phases of mammalian development, yet genomic targets of this process are largely unknown. We optimized methylated DNA immunoprecipitation for low numbers of cells and profiled DNA methylation during early development of the mouse embryonic lineage in vivo. We observed a major epigenetic switch during implantation at the transition from the blastocyst to...

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PMID: 21057502
DOI: 10.1038/ng.708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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