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Article

DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution.

PLoS genetics - 1 Mar 2009

Zhang Yingying, Rohde Christian, Tierling Sascha, Jurkowski Tomasz P, Bock Christoph, Santacruz Diana, Ragozin Sergey, Reinhardt Richard, Groth Marco, Walter Jörn, Jeltsch Albert

Abstract excerpt

Differential DNA methylation is an essential epigenetic signal for gene regulation, development, and disease processes. We mapped DNA methylation patterns of 190 gene promoter regions on chromosome 21 using bisulfite conversion and subclone sequencing in five human cell types. A total of 28,626 subclones were sequenced at high accuracy using (long-read) Sanger sequencing resulting in the measurement of the DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 21

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Source

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Identifiers

PMID: 19325872
DOI: 10.1371/journal.pgen.1000438
PMCID: PMC2653639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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