Article
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer.
Human molecular genetics - 1 Apr 2001
Baylin S B, Esteller M, Rountree M R, Bachman K E, Schuebel K, Herman J G
Abstract excerpt
Gene function in cancer can be disrupted either through genetic alterations, which directly mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene expression. The latter events are mediated by formation of transcriptionally repressive chromatin states around gene transcription start sites and an associated gain of methylation in normally unmethylated CpG islands in these...
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