Article

Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet Activation

2023-08-25

Abstract excerpt

<h4>Background</h4> Antibodies to β2-glycoprotein I (β2GPI) cause thrombosis in antiphospholipid syndrome, however the role of β2GPI itself in regulation of coagulation pathways in vivo is not well understood. <h4>Methods</h4> We developed β2GPI-deficient mice (Apoh -/- ) by deleting exon 2 and 3 of Apoh using CRISPR/Cas9 and compared the propensity of wild-type (WT) and Apoh -/- mice to develop thrombos...

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Literature Corpus work: a41f9c9e-5c72-5e3a-a863-c41b36e4743a
DOI: 10.1101/2023.08.23.554547

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