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Article

Protection against thrombosis in mice lacking PAR3.

Blood - 1 Nov 2002

Weiss Ethan J, Hamilton Justin R, Lease Katy E, Coughlin Shaun R

Abstract excerpt

The recent observation that knock-out of protease-activated receptor-4 (PAR4) ablates thrombin signaling in mouse platelets and protects against ferric chloride-induced thrombosis of mouse mesenteric arterioles suggests that thrombin's actions on platelets can play an important role in thrombosis. Complete ablation of thrombin signaling would be difficult to achieve in human beings because human platelets have 2...

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Source

Identifiers

PMID: 12384423
DOI: 10.1182/blood-2002-05-1470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Protection against thrombosis in mice lacking PAR3.PMID 12384423Read ↗

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.Semantic proximity Read ↗

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in miceSemantic proximity Read ↗

A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity.Semantic proximity Read ↗

A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet ReactivitySemantic proximity Read ↗

Protease-activated receptor 3 is a second thrombin receptor in humans.Semantic proximity Read ↗

Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity.Semantic proximity Read ↗

Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusionSemantic proximity Read ↗

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.Semantic proximity Read ↗

Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet ActivationSemantic proximity Read ↗

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.Semantic proximity Read ↗

Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.Semantic proximity Read ↗

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.Semantic proximity Read ↗

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