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Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV

2025-07-10

Abstract excerpt

Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges due to host immune responses not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model that recapitulates neuroinflammatory hallmarks, serving as a platform for preclinical gene therapy development. Utilizin...

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Literature Corpus work
7b492d9d-56f0-5ca6-a0f5-3f0ee8750619
DOI
10.1101/2025.07.07.662807
Open publication

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