Article

Glia-enriched stem-cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis

2024-06-24

Abstract excerpt

<h4>SUMMARY</h4> The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression in multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor ( SOX10 )-based protocol to accelerate oligodendrocyte differentiation from hiPSC-derived neural precursor cells, generating self-organizing forebrain organoids. These organoid...

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Literature Corpus work: a5146ab8-f21c-5169-8a79-af47ee169546
DOI: 10.1101/2024.06.20.597748

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