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A fully human pluripotent stem cell-derived blood-brain barrier model for clinically relevant disease modeling and selection of neurotropic adeno-associated viruses

2025-12-23

Abstract excerpt

<h4>Summary</h4> The blood-brain barrier (BBB) is a highly functionalized vascular interface which regulates the exchange of substances between the neural parenchyma and its periphery. BBB leakage, leading to its uncontrolled permeability, is increasingly recognized to facilitate the onset of neuropathologies and aggravate their clinical progression. In vitro models of the BBB have rapidly evolved into elaborated...

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Literature Corpus work
844f42aa-1688-5679-8baa-191996104324
DOI
10.64898/2025.12.21.695793
Open publication

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A fully human pluripotent stem cell-derived blood-brain barrier model for clinically relevant disease modeling and selection of neurotropic adeno-associated virusesDOI 10.64898/2025.12.21.695793
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