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Article

A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis.

Cell reports. Medicine - 20 Aug 2024

Fagiani Francesca, Pedrini Edoardo, Taverna Stefano, Brambilla Elena, Murtaj Valentina, Podini Paola, Ruffini Francesca, Butti Erica, Braccia Clarissa, Andolfo Annapaola, Magliozzi Roberta, Smirnova Lena, Kuhlmann Tanja, Quattrini Angelo, Calabresi Peter A, Reich Daniel S, Martino Gianvito, Panina-Bordignon Paola, Absinta Martina

Abstract excerpt

The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression in multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor (SOX10)-based protocol to accelerate oligodendrocyte differentiation from human induced pluripotent stem cell (hiPSC)-derived neural precursor cells, generating self-organizing forebrain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39121861
DOI: 10.1016/j.xcrm.2024.101680
PMCID: PMC11384947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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