Article

Chaperonin recognition of protein dynamics drives drug resistance

2026-06-07

Abstract excerpt

The emergence of drug resistance is typically driven by mutations that alter drug-target affinity, yet the role of host cellular machinery regulating these processes remains unclear. Here, we reveal that the chaperonin GroEL/S promotes drug resistance through recognition of protein dynamics. Using directed evolution of E. coli DHFR under antibiotic stress and varying GroEL/S expression, we identify a well-folded...

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Literature Corpus work: 0d6755c6-c5fd-55e0-9e11-2bc60ac5b4d0
DOI: 10.64898/2026.06.03.729952

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