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Article

Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily.

Scientific reports - 3 Mar 2020

Wu Hsin-Hui, Symersky Jindrich, Lu Min

Abstract excerpt

The rapid increase of multidrug resistance poses urgent threats to human health. Multidrug transporters prompt multidrug resistance by exporting different therapeutics across cell membranes, often by utilizing the H+ electrochemical gradient. MdfA from Escherichia coli is a prototypical H+ -dependent multidrug transporter belonging to the Major Facilitator Superfamily. Prior studies revealed unusual flexibility...

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Identifiers

PMID: 32127561
DOI: 10.1038/s41598-020-60332-8
PMCID: PMC7054563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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