Article

Breaking Glycolysis: Allosteric Hotspots for Multi-Target Drug Repurposing

2026-04-01

Abstract excerpt

<title>Abstract</title> <p> Glycolysis is essential for cellular energy production, making its enzymes attractive antimicrobial targets. Traditional strategies targeting conserved catalytic sites risk host toxicity due to limited species specificity. Allosteric sites—spatially distinct, evolutionarily divergent regulatory regions—offer selective inhibition but are challenging to detect experimentally. Here, we s...

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Literature Corpus work: f05c521e-ea6d-5d64-a2a9-0cb39d14bbb2
DOI: 10.21203/rs.3.rs-9149499/v1

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