Quantification of Membrane Protein Conformational Free Energy from Mutations and a Single Atom.

Abstract excerpt

Secondary active transporters are membrane proteins involved in moving substrates across the cellular membrane. Conformational dynamics underlie this process, allowing the transporter to sample at least two conformations, nominally grouped into inward- and outward-facing states. While studies of structure and dynamics have revealed atomistic insight into transport mechanisms and transport rates, the relative free...

Topics

• Escherichia coli Proteins
• Mutation
• Thermodynamics
• Protein Conformation
• Antiporters
• Escherichia coli
• Nuclear Magnetic Resonance, Biomolecular