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Article

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.

Nature communications - 6 Sept 2021

Harris Andrzej, Wagner Manuel, Du Dijun, Raschka Stefanie, Nentwig Lea-Marie, Gohlke Holger, Smits Sander H J, Luisi Ben F, Schmitt Lutz

Abstract excerpt

Pdr5, a member of the extensive ABC transporter superfamily, is representative of a clinically relevant subgroup involved in pleiotropic drug resistance. Pdr5 and its homologues drive drug efflux through uncoupled hydrolysis of nucleotides, enabling organisms such as baker's yeast and pathogenic fungi to survive in the presence of chemically diverse antifungal agents. Here, we present the molecular structure of...

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Identifiers

PMID: 34489436
DOI: 10.1038/s41467-021-25574-8
PMCID: PMC8421411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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