Article

Heritability Informed Power Optimization (HIPO) Leads to Enhanced Detection of Genetic Associations Across Multiple Traits

2017-11-12

Abstract excerpt

Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association statistics. We find optimal linear combinations of association coefficients across traits that are expected to maximiz...

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Identifiers and source

Literature Corpus work: 7b3be996-103c-5aea-83ac-894ba7b62c91
DOI: 10.1101/218404

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