Article

Beyond power: Multivariate discovery, replication, and interpretation of pleiotropic loci using summary association statistics

2015-07-08

Abstract excerpt

The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods which consider variant association with multiple traits jointly have been developed. However, most effort has been put on improving discovery power: how to replicate and interpret these discovered pleiotropic loci using multivariate methods has yet to be discussed fully. Using only multiple...

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Literature Corpus work: 2f8f5e20-2bb6-5995-a6c0-4ac42736b1af
DOI: 10.1101/022269

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