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Article

Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations.

PLoS genetics - 1 Nov 2022

Taraszka Kodi, Zaitlen Noah, Eskin Eleazar

Abstract excerpt

We introduce pleiotropic association test (PAT) for joint analysis of multiple traits using genome-wide association study (GWAS) summary statistics. The method utilizes the decomposition of phenotypic covariation into genetic and environmental components to create a likelihood ratio test statistic for each genetic variant. Though PAT does not directly interpret which trait(s) drive the association, a per trait...

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PMID: 36342933
DOI: 10.1371/journal.pgen.1010447
PMCID: PMC9671458

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