Article
Improving genetic prediction by leveraging genetic correlations among human diseases and traits.
Nature communications - 7 Mar 2018
Maier Robert M, Zhu Zhihong, Lee Sang Hong, Trzaskowski Maciej, Ruderfer Douglas M, Stahl Eli A, Ripke Stephan, Wray Naomi R, Yang Jian, Visscher Peter M, Robinson Matthew R
Abstract excerpt
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published...
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