Article

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

2023-07-11

Abstract excerpt

<h4>Summary</h4> Epigenetic inheritance refers to the faithful replication of DNA methylation and histone modification independent of DNA sequence. Nucleosomes block access to DNA methyltransferases, unless they are remodeled by DECREASE IN DNA METHYLATION1 (DDM1 Lsh/HELLS ), a Snf2-like master regulator of epigenetic inheritance. We show that DDM1 activity results in replacement of the transcriptional histone v...

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Literature Corpus work: 7dcc6feb-81f7-5da9-b772-a928a69f36a9
DOI: 10.1101/2023.07.11.548598

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