Article
N-terminal phosphorylation of HP1{alpha} promotes its chromatin binding.
Molecular and cellular biology - 1 Mar 2011
Hiragami-Hamada Kyoko, Shinmyozu Kaori, Hamada Daizo, Tatsu Yoshiro, Uegaki Koichi, Fujiwara Shinsuke, Nakayama Jun-Ichi
Abstract excerpt
The phosphorylation of heterochromatin protein 1 (HP1) has been previously described in studies of mammals, but the biological implications of this modification remain largely elusive. Here, we show that the N-terminal phosphorylation of HP1α plays a central role in its targeting to chromatin. Recombinant HP1α prepared from mammalian cultured cells exhibited a stronger binding affinity for K9-methylated histone...
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