Article
H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding.
Molecular cell - 19 Nov 2004
Fan Jun Y, Rangasamy Danny, Luger Karolin, Tremethick David J
Abstract excerpt
Controlling the degree of higher order chromatin folding is a key element in partitioning the metazoan genome into functionally distinct chromosomal domains. However, the mechanism of this fundamental process is poorly understood. Our recent studies suggested that the essential histone variant H2A.Z and the silencing protein HP1alpha may function together to establish a specialized conformation at constitutive...
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