Article
Evasion of Toll-like receptor 5 by flagellated bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
Andersen-Nissen Erica, Smith Kelly D, Strobe Katie L, Barrett Sara L Rassoulian, Cookson Brad T, Logan Susan M, Aderem Alan
Abstract excerpt
Toll-like receptor 5 (TLR5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. The alpha and epsilon Proteobacteria, including the important human pathogens Campylobacter jejuni, Helicobacter pylori, and Bartonella bacilliformis, require flagellar motility to efficiently infect mammalian hosts. In this study, we demonstrate that these...
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