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Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

13 Jan 2023

Abstract excerpt

Flagellin, the protein subunit of the bacterial flagellum, stimulates the innate immune receptor Toll-like receptor 5 (TLR5) after pattern recognition or evades TLR5 through lack of recognition. This binary response fails to explain the weak agonism of flagellins from commensal bacteria, raising the question of how TLR5 response is tuned. Here, we screened abundant flagellins present in metagenomes from human gut...

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PMID: 36608151
DOI: 10.1126/sciimmunol.abq7001

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